Lygos

Sustainable chemicals without petroleum.

Our target products are the specialty chemicals of today that can grow into the commodity chemicals of tomorrow. The primary hurdles restricting market growth of these chemicals is their current high production cost or environmentally hazardous production process. We address both these problems using a low-cost microbial fermentation technology, enabling over $25B in downstream value to be unlocked using our technology.

We make our products using commercially proven, acid-tolerant yeast. We have developed a suite of high-throughput engineering technologies that enable us to rapidly prototype and optimize our microbes, enabling low-cost, rapid technology scaleup.

Many of our target products are organic acids, compounds that are expensive to synthesize using petrochemistry but can be produced at high theoretical yield microbially. A high yielding process means less sugar is required to produce each kilogram of product, decreasing operating costs and lowering exposure to changing raw material (e.g., corn) prices. For some compounds, a theoretical yield greater than 100% can be achieved by sinking carbon dioxide. Low operating costs is a fundamental reason why microbial production of organic acids (e.g., itaconic, lactic, citric, and succinic acids) has been more successful than biofuels (e.g., farnesane, bio-diesel, butanol, and ethanol).


Lygos Berkeley, California, United States
Aug 22, 2020
Lygos is a synthetic biology company developing novel microbial technologies for the fermentative production of cannabinoids and specialty chemicals. Lygos identifies expensive, environmentally hazardous, and harmful chemical and petrochemical production processes used today and develops safe, renewable routes to manufacture the same products. Lygos is seeking to hire a skilled Fermentation Research Associate to support its needs to develop and evaluate strains producing a variety of products. Position Description Lygos is seeking a fermentation research associate candidate to set up, run, clean, and maintain bench-top level bioreactors (0.5L-15L). The successful candidate will have experience with general lab procedures, sterile technique, data interpretation and reporting in a fast paced and dynamic work environment. Responsibilities Execute fermentation experiments including: fermenter and media preparation, bioreactor sampling, fermenter cleaning, data entry and...
Lygos Berkeley, California, United States
Aug 09, 2020
Lygos develops novel microbial technologies for the fermentative production of commodity and specialty chemicals. Lygos identifies expensive, environmentally hazardous, and harmful processes used today and develops safe, renewable routes to the same products in order to achieve a more sustainable future. Lygos is seeking to hire a talented Scientist to support its protein and metabolic engineering needs to develop new microbial strains and processes to efficiently produce a variety of products. Position Description Strain design, construction and characterization, protocol development and exploratory research will all be necessary elements of the successful applicant’s duties. The successful applicant will be expected to advance critical aspects of Lygos’ strain engineering program through both effective individual and team efforts. Research objectives are milestone driven (biocatalyst yield, titer, and productivity) and require workflows directed toward achieving these...
Lygos Berkeley, California, United States
Aug 09, 2020
Lygos develops novel microbial technologies for the fermentative production of commodity and specialty chemicals. Lygos identifies expensive, environmentally hazardous, and harmful processes used today and develops safe, renewable routes to the same products in order to achieve a more sustainable future. Lygos is seeking to hire a skilled Research Associate to support its molecular biology needs to develop new microbial strains and processes to efficiently produce a variety of products. Position Description The successful applicant will work as part of a collaborative team to engineer microbial strains for improved production of bio-based chemicals. The position will involve the construction of combinatorial strain libraries, measurement and analysis of strain performance, and the development and application of assays to improve enzyme properties or interrogate cellular conditions. Requirements Responsibilities Work within the Biology team to efficiently and accurately...